See what’s next in healthcare from One and Two Discovery Square
At One and Two Discovery Square, discovery is more than a name it’s a mindset. Startups, research teams, and established companies plug into a growing ecosystem anchored by Mayo Clinic, surrounded by world-class talent and supported by a collaborative forward-thinking environment.
On-site events, shared workspaces, and purpose-driven design create the kind of community that transforms potential into progress.
One Discovery Square is the original anchor of Rochester’s innovation district—a purpose-built, 81,000-square-foot life science hub where discovery is woven into the design. Nearly fully leased, the building is home to startups, researchers, and educators working in close proximity to Mayo Clinic collaborators. With curated tenant programming, shared lab access, and a vibrant, high-touch environment, One Discovery Square fosters early-stage innovation and a culture of connection that accelerates scientific progress.
Now leasing, Two Discovery Square offers 120,000 square feet of flexible lab and office space designed for growth-stage companies and enterprise tenants. Positioned next door to Mayo Clinic, the building expands on the Discovery Square vision with scalable infrastructure, modern amenities, and room to grow. Whether you’re moving from concept to commercialization or expanding an existing footprint, Two Discovery Square delivers the space, support, and ecosystem to make your next breakthrough possible.
With direct access to Mayo Clinic’s 1.5 million square feet of cutting-edge research and lab space, tenants at Discovery Square are steps away from one of the world’s most respected medical institutions. From early-stage validation to commercialization, Mayo Clinic Ventures and core research services provide critical resources to accelerate discovery and bring innovations to market.
This unmatched proximity is part of a broader vision driven by Destination Medical Center (DMC)—a 20-year, $5.6 billion initiative positioning Rochester as a global destination for health and wellness. As a flagship anchor of the DMC innovation district, Discovery Square offers life science companies a front-row seat to world-class expertise, investment, and opportunity.
Rochester is a destination for discovery. This city isn’t just where Mayo Clinic is headquartered, it’s where health innovation thrives. With an emerging talent pipeline from the University of Minnesota and a quality of life that attracts world-class professionals, this city is engineered for growth.
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